In addition, the gene expression changes of PEG3, GADD45A, GDF5, FGF5, SOX2, ATP6V1C2, and other genes related to tissue repair and the anti-inflammatory cytokine IL-10 after MA provide clues for further research on the targets of acupuncture for RA treatment. The gene discussed is GADD45A; the disease is rheumatoid arthritis.