FUT8, whose expression is upregulated in most cancers, regulates the core fucosylation of PD-1 (120, 121), PD-L2 (122), TGF-β (123), TNFR (124), EGFR (78, 125, 126), B7H3 (127), α3β1 integrin (128), and E-cadherin (129) as well as that of mucins (130). This evidence concerns the gene FUT8 and cancer.