In summary, in this study we found that renal tubular death (apoptosis and pyroptosis), and inflammatory responses are important mechanisms in the sepsis-induced AKI, in which both pulmonary and renal SP-A involved in the lung-kidney crosstalk and directly or indirectly modulate lung and kidney inflammatory responses and renal tubular apoptosis, pyroptosis. Here, SFTPA2 is linked to Sepsis.