We furtherly analyzed renal injury score, the results showed infected KO mice had higher kidney injury score compared to infected WT and hTG mice; of interesting, septic hTG mice had higher renal injury score than infected WT mice (Figure 6C), suggesting lacking pulmonary and/or renal SP-A were more susceptible to sepsis-induced AKI. This evidence concerns the gene SFTPA2 and acute kidney injury.