Utilizing the GEPIA database, SYAP1 was found to be significantly expressed in tumor tissues in the majority of malignancies when examining the relative expression of SYAP1 in pan-cancerous tumors and adjacent tumors (Supplementary Figure 3) and LUAD patients with high SYAP1 expression have poorer OS (Supplementary Figure 4). The gene discussed is SYAP1; the disease is neoplasm.