SPP1 and cancer: • The CD8+ Texs are malignancy-related and TCR-dependent.• Primary CRC tumors with Liv.Mets may exhibit a stronger immunosuppressive niche compared to non-metastatic CRC tumors.• SPP1+ is mainly found in Liv.Mets as well as the potent phagocytosis of C1QC+ and may play an important role in tumor metastasis.• Proinflammatory DC3 is phenotypically formed by cancer cells in the CRLM.