• CXCL13 + T cells may perform similar functions in microsatellite unstable (MSI) tumors and are associated with a high response rate to checkpoint blockade.• Discovery of reduction of antigen presentation and anti-tumor immunity of CD40 + and CD27 + cells in tumors.• Communication between non-immune cells and immune cells expanded significantly in the tumor. The gene discussed is CXCL13; the disease is neoplasm.