• Tumor tissues:• CTLA4+ Tregs• CTLA4- Tregs• Th 1/Th 17 cells with high CXCL13 expression• MacrophagesAdjacent normal tissues:• Naive T cells (CD8-TCF 7 and CD4-CCR 7)• Tex cells(CD8- HAVCR2). The gene discussed is CXCL13; the disease is neoplasm.