In autoimmune lymphoproliferative syndrome (ALPS), which is the most prevalent genetic disease related to defective apoptosis of lymphocytes, mutations in N-Ras lead to a reduction in Bim (a pro-apoptotic protein), which results in decreased mitochondrial apoptosis and lymphocyte accumulation (3). The gene discussed is BCL2L11; the disease is autoimmune lymphoproliferative syndrome.