Interestingly, a spontaneous RasGRP1-disrupted mouse developed a lymph proliferative autoimmune inflammatory syndrome with a lupus-like aspect, such as anti-nuclear antibodies (ANA), anti-Smith antibodies (ASA), and anti-double-stranded DNA antibodies, splenomegaly, lymphadenopathy, and diffuse proliferative glomerulonephritis (75). The gene discussed is RASGRP1; the disease is systemic lupus erythematosus.