Although the involvement of the caspase-4 inflammasome in myocardial diseases such as myocardial reperfusion-induced microvascular injury has been reported (Sun et al., 2021), the roles of the caspase-4 inflammasome and the caspase-5 inflammasome in VMC have not been established and need more exploration. The gene discussed is CASP4; the disease is myocardial disorder.