The studies mentioned above, decreased IL-2 levels in the vaginal microenvironment may affect the clearance of high-risk HPV and lead to persistent infection of high-risk HPV, while persistent infection of high-risk HPV may cause the decreased secretion of IL-2 by local production of E6, E7, etc. (Trujillo-Cirilo et al., 2021), which promotes the development of cervical cancer. The gene discussed is IL2; the disease is cervical carcinoma.