After adjusting for all potential confounders including high-risk HPV infections, we observed the inverse linear dose-response associations between IL-2 levels and prevalence of CIN (P overall <0.01, P nonlinear < 0.01, CIN I), CIN I (P overall <0.01, P nonlinear= 0.01), and CIN II/III (P overall <0.01, P nonlinear = 0.62) (Figure 1). Here, IL2 is linked to cervical squamous intraepithelial neoplasia.