First, we demonstrated 99% conservation of 82 cystogenic genes, including 6 ADPKD-associated genes (PKD1, PKD2, IFT140, DNAJB11, ALG9, and GANAB), 1 ARPKD causative gene (DZIP1L), and 75 renal ciliopathy genes (Porath et al., 2016; Lu et al., 2017; Cornec-Le Gall et al., 2018; Besse et al., 2019; McConnachie et al., 2021; Senum et al., 2022). This evidence concerns the gene PKHD1 and autosomal dominant polycystic kidney disease.