All ADPKD-associated genes, including major causative gene PKD1 and PKD2 as well as genes recently linked to ADPKD such as IFT140, DNAJB11, GANAB, and ALG9, have zebrafish homologs (Supplementary Table S1) (Porath et al., 2016; Cornec-Le Gall et al., 2018; Besse et al., 2019; Senum et al., 2022). This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.