In a multinomial logistic regression model with patients without use of GLP-1 as the reference group, significant associations existed between TIR and the prevalence of islet function (baseline: P = 0.019;3months: P = 0.017; 6 months:P=0.001) after adjusting for age, sex, BMI, diabetes duration, HbA1c, blood pressure, and lipid profile (Table 4). This evidence concerns the gene GLP1R and diabetes mellitus.