Recently, detailed in silico analysis of available published data revealed that two TF genes, namely KLF11 and PAX4 – which previously enlisted as MODY-causing proteins – can not be included in the MODY list due to lack of co-segregation with diabetes and higher rate of same mutant genes in healthy population in addition to two other non-TF genes –BLK and APPL1 (5, 6). This evidence concerns the gene TF and diabetes mellitus.