• Glucose uptake and TCA cycle flux decreased, mitochondria was fewer in insulin-resistant offspring skeletal muscle of diabetes history (45–47). • O-GDM had decreased PPARGC1A in skeletal muscle (48). • Fatty acid flux into myotube and LPL expression were lower in offspring of T2DM parents (49). The gene discussed is PPARGC1A; the disease is gestational diabetes.