IL1B and gestational diabetes: • Male O-PGDM elevated bone marrow myeloid progenitors and total cellularity (123). • Splenocytes secrete more IL1β after GDM offspring fed HFD diet (124). • Neutrophil count fell down (123), the proliferative and chemotaxis ability of circulating lymphocytes were restrained (125, 126), activation of B cells was encouraged (127) in diabetic offspring mesenteric lymph nodes.