• Intrauterine hyperglycemia increased P300 and decrease SIRT1, accumulated H3K14ac in the promoter of Ngn1 and NeuroD2, disturbing neural distributions (106). • Hyperglycemia caused H3K9me2 accumulation in Sod2 promoter, increased ROS and inflammation in hematopoietic stem cells (150). • Reduced H3K27me3 and increased H3K27ac in promoter of Cartpt via inhibiting Ezh2 and activating CBP/P300, contributing to GDM subfertility (112). The gene discussed is SIRT1; the disease is gestational diabetes.