Confounding, ie, association of covariates with the predictor variables (platelet surface–associated CXCL14 and circulating CXCL14) and outcome variables (ACM, MI, and combined outcome) was present only for age as a confounder of the relationship between circulating CXCL14 and ACM, diabetes for the relationship between platelet surface–associated CXCL14 and ACM and the combined outcome, and left ventricular ejection fraction (LVEF) for the relationship between platelet surface–associated CXCL14 and circulating CXCL14 and ACM. The gene discussed is CXCL14; the disease is diabetes mellitus.