According to the bioinformatics data, APOEɛ4 may have a close relationship to the m6A methylation regulators (METTL3, METTL16, YTHDC2, LRPPRC) in brain tissue from AD patients, but the exact mechanism needs to be determined by further experimental studies (Du et al., 2021). This evidence concerns the gene METTL3 and Alzheimer disease.