A decrease in the expression levels of m6A methyltransferases METTL3, METTL14, and WTAP was observed in the brains of Tyrobp−/− mice compared to wild type mice, which is consistent with this trend found in the brains of AD patients (Zhao et al., 2021; Lv et al., 2022). Here, METTL14 is linked to Alzheimer disease.