At present, >200 casual genes have been identified for female infertility, and genes related to oocyte maturation defect (OOMD) such as ZP1 (OOMD1), TUBB8 (OOMD2), ZP3 (OOMD3), PATL2 (OOMD4), WEE2 (OOMD5), ZP2 (OOMD6), PANX1 (OOMD7), BTG4 (OOMD8), TRIP13 (OOMD9), REC114 (OOMD10), ASTL (OOMD11), FBXO43 (OOMD12) and TBPL2 have been discovered by high-throughput sequencing (Chen et al., 2017; Sang et al., 2018; Wang et al., 2020; Zhang et al., 2020; Zheng et al., 2020; Cao et al., 2021; Sang et al., 2021; Yang et al., 2021; Capalbo et al., 2022; Loeuillet et al., 2022; Maddirevula et al., 2022). The gene discussed is TUBB8; the disease is female infertility.