In contrast, in non-critically ill patients with COVID-19, P2Y12 blockade in addition to heparin compared to heparin alone did not result in increased odds of improvement in organ support-free days (142) and – equally to COX-1 inhibitors - only had a low likelihood of improving the number of organ support-free days in critically-ill COVID-19 patients when compared to patients without platelet inhibitors (149). The gene discussed is PTGS1; the disease is COVID-19.