NPPB and miotic rate: Similar to the findings for MR by Goliasch et al., Neuhold et al. in an analysis of almost 600 patients with chronic HF identified severe TR as a significant predictor in patients with mildly or moderately impaired LVEF or with NT-proBNP levels below the median (≤280 fmol/ml) but not in those with severely impaired LVEF or with NT-proBNP levels above the median (31, 64).