Second, we designed two chemically stabilized bisbenzylguanine(BB)-modified guide RNAs (BB-gRNAs or gMAVSs) to target simultaneously clusters 3 and 4 within MAVS at multiple sites and restore ADAR1-mediated RNA editing in these DLBCL-specific regions (Figure S10). The gene discussed is ADAR; the disease is diffuse large B-cell lymphoma.