This statement is further supported by our analyses in DLBCL derived cell lines (like RC-K8) which are capable of responding to stimulation through the RLR pathway (Figure S12C) and also by recent reports of an alternative pathway to MDA5/MAVS that can rescue the inflammatory phenotype mediated by loss of ADAR1 in mature immune cells63 (and which could be preferentially expressed in B cells or other cells of the immune system). The gene discussed is IFIH1; the disease is diffuse large B-cell lymphoma.