Although this is the case for three types of solid tumors studied (melanoma, lung adenocarcinoma and acinar pancreatic carcinoma,26,27,29,60 we discovered that in DLBCL, one of the most common and aggressive types of B cell lymphomas, reduction or loss of ADAR1 was irrelevant to key proximal measures of inflammation within the tumor microenvironment (Figure 5). Here, ADAR is linked to melanoma.