MAVS is known to aggregate in response to ligand (viral RNA) bound RIG-I (DDX58) or MDA5 (IFIH1); however, viral infection did not correlate with MAVS (or ADAR1) levels in DLBCL: even though some of the samples showed evidence of viral infection (illustrated by HBV+ or EBV+ status), the editing rate (as defined by the AEI index) was not altered (Figure S6). The gene discussed is RIGI; the disease is viral infectious disease.