For example, loss of epithelial cadherin (E-cadherin, encoded by CDH1) is considered as the most prominent cancer driving event in invasive lobular carcinoma of the breast (ILC) (Ciriello et al., 2015), as well as hereditary and a subset of sporadic diffuse gastric cancer (Wang et al., 2014; Cho et al., 2017). Here, CDH1 is linked to invasive lobular breast carcinoma.