Later studies showed that activating mutations of Notch 1 and inactivating mutations of the tumor suppressor gene (TSG) FBXW7 were common in T-ALL (Weng et al., 2004; Malyukova et al., 2007; Maser et al., 2007; Thompson et al., 2007). This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.