CDH2 and cancer: In line with these findings, expression of N-cadherin in mouse cancer models supports the notion that N-cadherin and FGFR synergistically potentiate downstream MAPK and AKT signaling with EMT to promote cancer metastasis (Shintani et al., 2006; Hulit et al., 2007; Su et al., 2012; Qian et al., 2014).