Merlin (encoded by NF2), which activates Hippo kinases (Hamaratoglu et al., 2006; Zhang et al., 2010; Yin et al., 2013), is also frequently mutated in neurofibromatosis (Asthagiri et al., 2009) and malignant mesothelioma (Murakami et al., 2011). Here, NF2 is linked to neurofibromatosis.