In the setting of sporadic cancers, somatic deleterious mutations and deletions of PTCH1 and SUFU have been observed in a subset of BCCs (Teh et al., 2005; Jayaraman et al., 2014) and medulloblastomas (Raffel et al., 1997; Taylor et al., 2002). The gene discussed is PTCH1; the disease is medulloblastoma.