WWTR1 and cancer: As the majority of these studies utilized simple cell line models, studies in model organisms, patient-derived organoids [reviewed in (Kim et al., 2020)], or tumor-on-a-chip models [reviewed in (Sontheimer-Phelps et al., 2019; Liu et al., 2021)] could provide further insight into the interplay between CCC and Hippo-YAP/TAZ signaling and its role in cancer.