In fusiform gyrus, seven novel candidate genes were identified co-expressed in AD, including FNDC3A, NRIP1, PKN2, and TMTC2, as well as differentially co-expressed genes such as FAM153B, CYP2C8, and CKMT1B. In addition, the Toll-like Receptor Cascades are the most prominent pathway involved in dementia processes. Here, PKN2 is linked to Alzheimer disease.