MAPT and Alzheimer disease: We identified pathways enriched for G Proteins and consequently, for G protein-Coupled Receptors GPCRs, which are involved in the phosphorylation of tau through diverse downstream kinases, such as GSK-3β, CDK-5 and ERKs signaling cascade, and interacts with β-site APP Cleaving Enzyme 1 (BACE1), both which play a major role in AD (Zhao et al., 2016; Deyts et al., 2019; Chidambaram and Chinnathambi, 2020).