These results corroborate long-standing research linking neurodevelopmental disorders to mitochondrial dysfunction (oxidative phosphorylation; Giulivi et al., 2010; Rossignol and Frye, 2012) immune regulatory systems (Granzyme A, Sirtuin; Careaga et al., 2017; Meltzer and Van de Water, 2017; Hughes et al., 2018), and cell proliferation and apoptosis (Granzyme A, HIPPO, RhoGDI, Sirtuin; Dong et al., 2018; Courchesne et al., 2019). The gene discussed is GZMA; the disease is neurodevelopmental disorder.