ANKS1B and tuberous sclerosis: Indeed, most (if not all) identified ASD mouse models such as those for Fragile X (Bhakar et al., 2012), tuberous sclerosis (Auerbach et al., 2011), Angelman (Mabb et al., 2011) Phelan McDermid (Sarowar and Grabrucker, 2016), and ANKS1B syndromes show deficits in diverse forms of synaptic function as well as altered neuronal and synaptic morphology (Tindi et al., 2015; Carbonell et al., 2019).