In summary, SCLC and neuroblastoma exhibit not only differential copy-number gains but also differential transcriptional regulation for Myc family genes with regard to their NE status, with MYC transcriptionally upregulated in the non-NE state, MYCL preferentially amplified in high-NE-score SCLC, and MYCN preferentially amplified and transcriptionally upregulated in high-NE-score neuroblastoma. Here, MYCN is linked to small cell lung carcinoma.