In the high-NE-score lines of both SCLC and neuroblastoma, we found higher apoptotic machinery components (Smac, Bcl-2, Bim, and Bax), DNA repair proteins (MSH2 and MSH6), translation inhibitor 4E-BP1, and microtubule regulator Stathmin. The gene discussed is MSH2; the disease is small cell lung carcinoma.