Combined analysis of copy number, gene expression, and NE scores in the CCLE cell line dataset revealed upregulation of MYC expression in the low-NE-score lines without copy-number gain, suggesting the transcriptional activation of MYC expression in the non-NE state for both SCLC and neuroblastoma (Fig. 4G). The gene discussed is MYC; the disease is small cell lung carcinoma.