In the low-NE-score lines of both SCLC and neuroblastoma, we observed higher levels of receptor tyrosine kinases and their phosphorylation (EGFR, EGFR_pY1068, HER2_pY1248, and VEGFR2), higher levels of Hippo signaling components (YAP, YAP_pS127, and TAZ), proinflammatory proteins (p62, NF-kB-p65_pS536, PAI-1, and annexin 1), ribosome biogenesis markers (S6_pS240_S244 and S6_pS235_S236), and cell adhesion proteins (paxillin and CD49b). Here, ITGA2 is linked to neuroblastoma.