Although these transcription factors have not been used to classify neuroblastoma samples, when we examined their expression in neuroblastoma cell lines, we observed a pattern of segregation by NE score similar to SCLC—while high-NE-score neuroblastoma lines were found to have high expression of ASCL1 or NEUROD1, low-NE-score neuroblastoma lines had high expression of YAP1. Here, ASCL1 is linked to small cell lung carcinoma.