PTGS2 and cancer: The HIF1A gene presents some genetic polymorphisms that have been studied in different health conditions and were associated with cancer susceptibility and prognosis, coronary artery disease, and metabolic and cardiovascular risk factors.13 - 18 Genetic polymorphisms in RANKL (receptor activator of nuclear factor-κB ligand) and COX2 (cyclooxygenase-2) genes associated with OTM were shown to affect the expression of those genes in human PDL (hPDL) fibroblasts during simulated orthodontic compressive pressure.