The virus‐released cancer antigens of OV‐associated molecular patterns, such as viral capsid constituents, proteins, and viral RNA and DNA, stimulate Toll‐like receptors and the danger signals that are necessary to initiate innate and adaptive immunity.[215] In addition, oncolytic virus triggers tumor cell ICD by increasing the surface expression of calreticulin and the synthesis of ATP and HMGB1, which trigger immune activity and initiate anti‐tumor immunity.[216, 217]. Here, HMGB1 is linked to neoplasm.