HMGB1 and cancer: demonstrated that UV‐irradiated cancer cells could induce resistance to subsequent rechallenge with cancers.[187, 188] During apoptosis, the induction of specific DAMPs, such as membrane translocated calreticulin (CRT) and the release of heat shock protein 70 (HSP70) and HMGB1 determines the immunogenicity of UV‐irradiated cancer cells.