HCC exosomes‐pulsed DCs induced a significantly stronger immune response and suppressed tumor growth in HCC mice compared to DCs pulsed with cell lysates.[65, 66] The tumor immune microenvironment was significantly improved in HCC mice treated with TEX‐pulsed DCs; they showed increased number of T lymphocytes, elevated levels of IFN‐γ, and decreased levels of IL‐10 at the tumor site.[67]. This evidence concerns the gene IFNG and neoplasm.