[178] Several studies use whole water‐soluble tumor lysates to pulse autologous DCs to treat tumors; this is effective in many cancers, such as melanoma, Neuro‐2a neuroblastoma, glioblastoma multiforme (GBM), renal tumor, and non‐small cell lung cancer.[39, 179] Supporting the use of whole water‐soluble tumor lysates as cancer vaccine is a prior phase II trial for GBM, which showed an expansion of CD8+ T cells and CTL against tumor antigens. This evidence concerns the gene CD8A and glioblastoma.