To investigate the role of HRG in mice with intact immune activeness, WT and KO‐HRG mice were tail vein injected with mouse HCC cell line Hepa 1−6, and we found that KO‐HRG mice showed significantly higher intrapulmonary metastatic tumour loads than WT mice (Figures 2K–N). The gene discussed is HRG; the disease is hepatocellular carcinoma.