HRG and cancer: However, when human peripheral blood neutrophils were pre‐treated with a cancer cell CM containing HRG, the number of neutrophils attracted by the medium of neutrophils was significantly reduced, and by contrast, the neutrophil medium pre‐treated with CM of HRG knockdown attracted more neutrophil migration (Figure 4A), indicating that HRG may act on neutrophils and regulate the secretion of related chemokines to impact the recruitment of neutrophils.