TL alone (HR = 0.75, 95% CI 0.73–0.77) gave the K index 0.58 for AD/ADRD versus 0.59 from APOE genotype alone (HR [e3e4 vs. e3e3] = 2.29, 95% CI 2.17–2.42; HR [e4e4 vs. e3e3] = 6.29, 95% CI 5.78–6.85; HR [e2e4 vs. e3e3] = 1.40, 95% CI 1.19–1.64; HR [e2e3 vs. e3e3] = 0.85, 95% CI 0.77–0.93; HR [e2e2 vs. e3e3] = 1.04, 95% CI 0.73–1.49; HR [e1e2 vs. e3e3] not reported due to enormous uncertainty from a low number n = 3). This evidence concerns the gene APOE and Alzheimer disease.