For the subtypes of AD/ADRD, TL (HR = 0.75, 95% CI 0.71–0.79) and APOE genotype (HR [e3e4 vs. e3e3] = 4.00, 95% CI 3.51–4.55; HR [e4e4 vs. e3e3] = 13.33, 95% CI 11.19–15.89; HR [e2e4 vs. e3e3] = 1.60, 95% CI 1.06–2.39; HR [e2e3 vs. e3e3] = 0.70, 95% CI 0.52–0.93; HR [e2e2 vs. e3e3] = 0.75, 95% CI 0.24–2.35) produced the K indexes, 0.58 and 0.64, for AD only, relative to 0.81 from the age‐and‐sex model and 0.83 from the full model (Table S13). This evidence concerns the gene APOE and Alzheimer disease.