CNR1 and obesity due to melanocortin 4 receptor deficiency: In this line, a study in individuals with EDs and obesity described a negative association between BMI and CB1R availability in both hypothalamic (i.e., homeostatic pathway) and mesolimbic regions (i.e., hedonic pathway), supporting the existence of compensatory mechanisms that seek to counteract the abnormal activity of the eCB system in EWC [58].