TFF2 and Alzheimer disease: CAMs analysis showed upregulation of sVCAM-1, sPECAM-1 (reflecting endothelial damage), sP-, sL-Selectin (reflecting vascular changes), sNCAM and sICAM-1 (expressed in response to infections) in CI-AD (p < 0.037) and only sP-Selectin (p < 0.030) in CI-NAD compared to CU (Fig. 2C).