CXCR4 and lung cancer: The results in Fig. 6B show that NPM3 expression was negatively correlated with CCL2, CXCR4, CCL5 or CXCL10, and positively correlated with CXCL5. In addition, tumor infiltrating B cells exerts anti-tumor immunity by secreting tumor-specific antibodies, facilitating T-cell responses, and maintenance the structure and function of tertiary lymphoid structures, which are all responsible for the beneficial outcome of lung cancer [50–53].