BCR and Familial prostate cancer: Kaplan–Meier analysis has also shown that ZNF154 methylation level was associated with biochemical recurrence (BCR) (p = 0.005) in prostate cancer, and that ZNF154 could be an independent factor for BCR prediction by using univariate and multivariate Cox regression analysis (p = 0.035, HR = 8.218) [21].