In our experiments, we proved the miR-146a-5p mimic could down-regulate TRAF6 in SM-induced ALI, then we found that miR-146a-5p-overexpressing extracellular vesicles (miR-146a-5p+-EVs) has the similar effects, which is similar to the effects of siTRAF6. Here, TRAF6 is linked to acute respiratory distress syndrome.