Specifically, the abundance of α-SMA+ CAFs correlated with CD163+ MØs, in addition, we observed significantly positive correlations among α-SMA+ CAFs, CD163+ MØs and anti-tumor immune cells (i.e. CTLA4, FOXP3, CD4 and CD8 T cells, Fig. 1E-G). The gene discussed is ACTA1; the disease is neoplasm.