Among the 18 sex related genes, five infertility-related genes were identified, including fancm, slirp, arid4a, ak7, and akt1. Hypogonadism have been noted in both male and female mice with a fancm deficiency [33], and a homozygous fancm frameshift pathogenic variant causes male infertility in humans [34]. The gene discussed is ARID4A; the disease is male infertility.