CD56 (HR = 0.78, 95%CI: 0.64–0.95, P = 0.02), NKp46 (HR = 0.78, 95%CI: 0.63–0.95, P = 0.02), granzyme B (HR = 0.92, 95%CI: 0.85–0.99, P = 0.03), and perforin (HR = 0.78, 95%CI: 0.63–0.95, P = 0.02) were correlated with postoperative RFS of patients with HCC (Fig. 6). Here, PRF1 is linked to hepatocellular carcinoma.