AVPR2 and experimental autoimmune encephalomyelitis: Overexpression of another NADH dehydrogenase, the NADH-ubiquinone oxidoreductase (NDI1), has been shown to ameliorate the loss of optical nerve axons and retinal ganglion cells in a mouse model of experimental autoimmune encephalomyelitis, protecting mice from permanent visual loss [151, 152], even though the impact of NDI1 expression on NAD levels was not mentioned.