CFTR and cystic fibrosis: Even though our stimulated C57BL/6 murine macrophages differ from CFTR-defected cystic fibrosis macrophages, both types of cells exert similar regulatory properties of inflammation [27]: namely, they (i) increase the secretion of pro-inflammatory mediators, (ii) sustain hyperinflammation, and (iii) have increased responsiveness to external stimuli.