To test whether the exacerbated GC-induced insulin resistance observed in Ehmt2K182R/K182R mice is due to EHMT2’s function in the liver, we infected Ehmt2K182R/K182R mice with adeno-associated virus serotype 8 (AAV8) expressing GFP (AAV8-GFP) or human EHMT2 (AAV8-hEHMT2). This evidence concerns the gene EHMT2 and Insulin resistance.