Moreover, we identified cancer-specific signatures that reflect distinct mutational processes involved in the development of each cancer type, for instance, UV-exposure associated signature DBS1 is significant in melanoma, SBS12/SBS16/ID16 are in breast cancer, while Aflatoxin exposure signature SBS24 and indirect effects of AID signature (SBS85) are highly informative in prostate cancer (see Supplementary Fig. S3). This evidence concerns the gene AICDA and breast cancer.