AICDA and melanoma: Moreover, we identified cancer-specific signatures that reflect distinct mutational processes involved in the development of each cancer type, for instance, UV-exposure associated signature DBS1 is significant in melanoma, SBS12/SBS16/ID16 are in breast cancer, while Aflatoxin exposure signature SBS24 and indirect effects of AID signature (SBS85) are highly informative in prostate cancer (see Supplementary Fig. S3).