Second, to address the translatability of Jagged1 in an ocular setting, we showed by immunohistochemistry on postmortem human eyes with anatomical signs of dry AMD by means of subretinal drusen deposits and retinal pigment epithelium (RPE) changes, that Jagged1 is occasionally expressed by the inner endothelial cell layer of choroidal blood vessels. Here, JAG1 is linked to dry age related macular degeneration.