Since LOXL3-K35/K36A has the major canonical activity of LOXL3 in the secreted medium (Supplementary Fig. 2g, h), but presents a lack of the ability to enter into mitochondrial (Fig. 2f, g, Supplementary Fig. 2d, e), thus, the restored expression of LOXL3-K35/K36A in LOXL3-knockdown cells could ascertain the role of LOXL3 in HCC chemoresistance regulation through the canonical function or not. This evidence concerns the gene LOXL3 and hepatocellular carcinoma.