In low-dose Oxaliplatin treatment test using patient-derived xenograft (PDX) models, the group with lower levels of both pLOXL3-S704 and DHODH showed significant sensitivity to Oxaliplatin (Fig. 7e), indicating an appropriate context for human HCC patients was required for selecting Oxaliplatin treatment. The gene discussed is DHODH; the disease is hepatocellular carcinoma.