To precisely calculate the correlation between AK2, LOXL3-S704 phosphorylation, and DHODH, we stained the tumor tissues of the 60 HCC patients using antibodies against AK2 while pLOXL3-S704 and DHODH were measured previously (Supplementary Fig. 7c, d). Here, AK2 is linked to hepatocellular carcinoma.