PFKFB3-NF-κB signaling induced the production of CXCL2 and CXCL8 in tumor-infiltrating monocytes, increased levels of CXCL2 and CXCL8 in monocytes and promote infiltration of oncostatin M-producing neutrophils in human hepatocellular carcinoma tissues [29]. This evidence concerns the gene OSM and neoplasm.