Progression-free survival (PFS) analysis showed high PFKFB3 expression was significantly correlated with poor prognosis for TCGA cases of ACC (HR = 3.13, logrank p = 0.0006), COAD (HR = 1.72, logrank p = 0.0035), KIRP (HR = 1.68, logrank p = 0.0550), sarcoma (SARC, HR = 1.58, logrank p = 0.0077), and uveal melanoma (UVM, HR = 3.63, logrank p = 0.0035, Figure 2B), and disease-free survival (DFS) analysis showed similar results in Figure 2D. The gene discussed is PFKFB3; the disease is adrenal cortex carcinoma.