PFKFB3 and neoplasm: The mRNA expression level of PFKFB3 was markedly elevated in tumor tissues of colon adenocarcinoma (COAD), cholangiocarcinoma (CHOL), head and neck squamous cell carcinoma (HNSC), stomach adenocarcinoma (STAD), and thyroid carcinoma (THCA) compared with the respective non-tumor tissues (Figure 1A).