PFKFB3 and malignant colon neoplasm: PFKFB3 protein level was analyzed by the CPTAC dataset, and the results showed that the protein level of PFKFB3 in colon cancer (p = 9.8E-03), uterine corpus endometrial carcinoma (UCEC, p = 5.4E-13), and LUAD (p = 1.1E-09) was much higher than in non-tumor tissues, while lower expression of PFKFB3 was observed in OV (p = 9.3E-03), KIRC (p = 1.1E-05), and breast cancer (p = 6.4E-05, Figure 1C).