However, PFKFB3 mRNA level was lower in tumor tissues of breast invasive carcinoma (BRCA), bladder urothelial carcinoma (BLCA), kidney renal clear cell carcinoma (KIRC), kidney chromophobe (KICH), kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), lung squamous cell carcinoma (LUSC), lung adenocarcinoma (LUAD), prostate adenocarcinoma (PRAD), lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), and thymoma (THYM) compared with corresponding non-tumor tissues (Figure 1A and Supplementary Figure 2). Here, PFKFB3 is linked to squamous cell lung carcinoma.