Epithelial cell adhesion molecule (EpCAM), CD44 and more recently spalt-like transcription factor 4 (SALL4) are specific CSC-related markers that impact the biology of HCC.6, 8 Their expression has been linked to higher tumour grade, lymphovascular invasion, tumour recurrence and poorer survival. Here, SALL4 is linked to hepatocellular carcinoma.