The result demonstrated that presence of LH severe held significantly lower risk of all colorectal lesions (adjusted OR = 0.48, 95%CI = 0.27–0.86, P = 0.01) and adenoma (adjusted OR = 0.47, 95%CI = 0.26–0.86, P = 0.01) (Table 5). The gene discussed is PLOD1; the disease is adenoma.