SSRP1 and myelofibrosis: Furthermore, SSRP1 a subunit of the FACT complex, was identified as one of the top 20 hits from an shRNA screen to identify critical genes in myelofibrosis [13] and since NF-ĸB has been reported to be activated in MF [14, 15] we hypothesised that CBL0137 may have utility in the treatment of MF.