THOC5 and myeloproliferative disorder: Further we have previously shown disruption of RNA processing in MPLW515L oncogene-driven myeloproliferative disorders via a novel THO complex pathway [23] and that THOC5 is not only a common phosphorylation target of numerous leukaemogenic oncogenes [30] but also plays a role in Myc regulation [23, 31] a target of CBL0137 [32].