CXCR3 and neoplasm: The elevated levels of Ifng further induce antitumor immune activity in tumors, leading to increased CXCL9 expression from tumor cells; CXCL9 then recruits CXCR3+ immune cells, such as cytotoxic CD8+ T cells and NK cells, into cancers to increase effector immune cell infiltration (39, 40).