Since SRC-3 KO Tregs have a tumor-eradicating activity and a suppressive activity against WT Tregs, we wished to determine whether a “single injection” of ACT with purified SRC-3 KO Tregs would eradicate preexisting E0771 tumors growing in wild-type mice by suppressing the inherent function of WT Tregs. This evidence concerns the gene NCOA3 and neoplasm.