The most frequently mutated factors include the H3K4 mono-methyltransferases MLL3 and MLL4 (encoded by the genes KMT2C and KMT2D, respectively) and their cofactor, the H3K27 demethylase UTX (KDM6A); the prevalence of mutations affecting these factors indicates their broad roles as tumor suppressors (12, 13). The gene discussed is KDM6A; the disease is neoplasm.