KMT2D and neoplasm: To determine the antitumor activity of LTX in MLL4-mutant tumors, we s.c. implanted HCT116 cells into the right flank of mice and treated the mice with LTX (25 mg/kg) or vehicle control (DMSO) i.p. when tumor size reached 100 mm3 (day 6 after implantation).