KMT2C and colorectal cancer: Similar GO terms were also enriched for genes downregulated in MLL3/4 KO versus WT mESCs (e.g., cytoskeleton organization, matrisome associated, and cell junction organization) (Supplemental Figure 1E and Supplemental Figure 6D), suggesting that loss-of-function MLL4 mutation in colorectal cancer shares similar gene expression features with mESC depleted of MLL3/4.