LEP and obesity due to melanocortin 4 receptor deficiency: An association between higher levels of CRP and impairment in cognitive flexibility was observed,17 or it was found for women only,18 while other studies failed to replicate this finding.19 Leptin has been shown to be an important factor associated with attentional performance among individuals with obesity.20 After bariatric surgery, reduced inflammation and changes in adipokines are observed, indicating that reduced inflammation may improve cognition after bariatric surgery.