A study by Lin et al. studied that miR-4454 promoted hepatocellular carcinoma progression by targeting Vps4A and Rab27A, while miR-4454 inhibitor and miR-4454 inhibitor-mediated exosomes significantly inhibited hepatocellular carcinoma cell proliferation, migration invasion and angiogenesis and accelerated cycle arrest, apoptosis and ROS(Lin et al., 2021). The gene discussed is VPS4A; the disease is hepatocellular carcinoma.