FOXO1 and diabetes mellitus: For instance,14-3-3/FOXO1 stabilization could inhibit FOXO1-fusion proteins inrare cancers and correct metabolism in diabetes.43,44 Additionally, 14-3-3-mediated inhibition of C-RAF is strongly implicatedin RAS-mediated cancers and in the developmental disorder Noonan’ssyndrome, where mutations in C-RAF and other proteins in the pathwaylead to slight upregulation of MAP kinase signaling.32,39