A detailed differential diagnosis of these disorders should then be performed to exclude or confirm comorbidities and treat them (including hypothyroidism, hypopituitarism of somatotropin, premature or early puberty with a poor growth prognosis, celiac disease, autoimmune diseases, emotional deprivation, poor nutrition, vitamin deficiencies, congenital heart and kidney defects). This evidence concerns the gene GH1 and autoimmune disease.